Which medication is effective in smoking cessation?

Bupropion is an effective medication for smoking cessation primarily due to its ability to influence neurotransmitter systems related to addiction and mood. As an atypical antidepressant, it primarily works by inhibiting the reuptake of dopamine and norepinephrine, which can help alleviate withdrawal symptoms and cravings associated with nicotine dependence. Furthermore, its stimulant-like qualities can offset some of the depressive symptoms and lethargy that may occur when a person stops smoking.

While nicotine gum is also a well-known aid for quitting smoking, it works by providing a low dose of nicotine, addressing cravings rather than altering the underlying factors of addiction. Varenicline is another option that targets nicotine receptors, reducing both cravings and withdrawal symptoms, and it is also effective in smoking cessation. Escitalopram is primarily an antidepressant and not indicated for smoking cessation, hence it is not considered effective for this purpose.