When a prescription for phenytoin mixed in dextrose is presented, what should the nurse do?

When phenytoin is mixed in dextrose, it is important for the nurse to question the prescription because phenytoin is not compatible with dextrose solutions. This incompatibility can lead to the precipitation of the drug, which would render it ineffective and potentially dangerous if administered to the patient. Phenytoin should ideally be mixed with normal saline for intravenous administration, as this allows for proper solubility and bioavailability.

Addressing the need for proper compatibility is crucial to ensuring patient safety and effective treatment. If a nurse encounters a medication order that raises concerns about its formulation or compatibility, it’s appropriate to communicate with the healthcare provider for clarification or a change in the prescription. This action helps prevent potential adverse reactions and ensures that the patient receives the most effective and safe treatment possible.