What is a common effect of trazodone when used as an antidepressant?

Trazodone, when used as an antidepressant, is well known for its sedative effects, which primarily arise from its properties as a serotonin antagonist. It is often prescribed not only for depression but also for insomnia due to its ability to promote sleep. The mechanism of action involves blocking the serotonin receptor 5-HT2A, which contributes to its calming effects, leading to drowsiness and sedation.

While some individuals may experience alterations in weight or appetite as side effects, the most characteristic and commonly reported effect of trazodone, particularly in the context of its use as an antidepressant, is this sedative effect. Its serotonergic activity, combined with its antihistaminic properties, enhances its sedative quality, making it distinct from other antidepressants that may not have such strong sedative effects.