If a client is prescribed cyclobenzaprine for muscle spasms, when should the nurse withhold this medication?

Cyclobenzaprine is a muscle relaxant that is contraindicated in clients taking monoamine oxidase inhibitors (MAOIs) due to the risk of serious drug interactions. Specifically, combining cyclobenzaprine with MAOIs can lead to increased levels of serotonin and potentially result in serotonin syndrome, a serious condition characterized by symptoms such as confusion, hallucination, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, and muscle spasm. Given these risks, it is essential for healthcare providers to ensure that clients are not concurrently using MAOIs before prescribing cyclobenzaprine.

While other conditions listed may warrant caution or monitoring, they do not represent absolute contraindications. Therefore, withholding cyclobenzaprine when a client is on MAOIs is a critical safety measure to prevent severe adverse effects.